One month after losing by a final of 112-57 to the Lakers, Cleveland shocked the defending champs with a 104-99 win on their home floor.
Ramon Sessions scored 32 points for the Cavaliers, who snapped a 26-game losing streak last week by defeating the Clippers. Antawn Jamison and Anthony Parker chipped in 19 and 18 points respectively.
The Lakers head into the All-Star break losing the final three games of their 'Grammy' road trip.
Pau Gasol had 30 points and 20 boards, but Kobe Bryant managed to score just 17 points on 24 shots from the floor and turned the ball over seven times.