Jonas Valanciunas broke a bone in his left hand during Friday's game.
Valanciunas will undergo further tests before the Toronto Raptors determine how long he will be sidelined.
Valanciunas broke the same bone -- in his right hand -- during his 2012-13 rookie season and missed 18 games.
"It's unfortunate, and we're definitely going to miss him because of what we do, so it's next man up right now," Kyle Lowry said.