LeBron James had 24 points, eight assists and seven rebounds in return game, a 122-115 win over the Indiana Pacers.
James missed the previous six games due to his ankle injury.
"Let the chips fall where they may. As simple as that. We're ready to go," said James after the game, discussing the Western Conference standings.
Currently in seventh place, the Lakers would need a win Sunday against the Pelicans and a Blazers loss to move out of the play-in tournament.
Frank Vogel said he did not know how much he would play certain players in back-to-back games.
"We'll meet with the medical team and see where everybody's at, in terms of the guys coming back from injury. And we'll make a decision on who's in and who's not in tomorrow."