The Orlando Magic announced that forward Jonathan Isaac will miss the entirety of the 2021-22 season. Isaac has been working towards a return, but has now been ruled out for the remainder of the season.

Isaac did not play during the 2020-21 season either. He's been out since suffering multiple knee injuries on August 2, 2020. Isaac was injured while going up for a shot against the Sacramento Kings in the NBA Bubble at Walt Disney World during the resumed 2020 season.

Isaac was thought to be lost for the year during the 2019-20 season when he suffered a knee injury on January 1, 2020. The pause of that season allowed Isaac to get back on the floor when play resumed that summer. It was in his second game in the bubble that he tore his left ACL and meniscus, which has kept out since.