No. 7 Villanova topped No. 3 Syracuse at the Carrier Dome on Saturday afternoon.
Maalik Wayns scored 17 of his 21 points in the first half of the Wildcats' 83-72 victory.
Syracuse had won 16 straight at the Carrier Dome dating to last February, but disappointed a season-high crowd of 33,736, second-largest in the building's history.