The Cavaliers will be without Anderson Varejao for the remainder of the season.
Varejao has a torn ankle tendon that will require surgery.
"It's a big blow," coach Byron Scott said. "Arguably, he's been our best player."
Varejao suffered the injury while running in practice on Thursday as the Cavaliers prepared for a five-game road trip.
He underwent a second MRI on Sunday that revealed "a complete tear of the peroneus longus in the midfoot of the right ankle and foot."
Varejao Out For Season With Torn Ankle Tendon