Andre Iguodala will miss at least two weeks due to a sprained left ankle.
"It's a really big deal," Steve Kerr told reporters.
Iguodala suffered the injury late in the third quarter on Friday.
Iguodala and Damian Lillard pursued a loose ball, and Lillard wound up undercutting Iguodala and rolling over his ankle.
"He got it good," Iguodala said.
An MRI confirmed the ankle sprain.