Al-Farouq Aminu is expected to miss two to three weeks with a right ankle sprain.
Aminu is averaging 9.4 points, 8.1 rebounds and a team-high 1.3 blocks in 30.2 minutes per game.
"It's tough," Blazers point guard Damian Lillard said on Thursday night. "Chief (Aminu) is a huge part of our team. He does a lot of things that might not get mentioned all the time, might not show up on the stat sheet, but he's as big a part of our team as just about anybody. Whatever the situation might be somebody's going to have to step up and we're going to have to figure out a way to get some wins."