LaMarcus Aldridge suffered a sprained right ankle when attempting to block a drive by Rajon Rondo in the first quarter of Wednesday's loss to the Pelicans.
Aldridge returned in the second period before exiting for good with eight points and three rebounds in 13 minutes.
The Spurs were already without Pau Gasol in the game.
"Yeah, I think he'll be fine. I'm hoping he'll be fine," Rudy Gay said of Aldridge after the game. "We obviously need our big dog. He's a soldier, he'll play."